Personalizing Behavioral Interventions Through Single-Patient (N-of-1) Trials

Prioritising drugs for single patient (n-of-1) trials in palliative care.

Many of the drugs prescribed commonly to palliative care patients have potentially significant side-effects and are of unproven benefit. The acquisition of evidence to support the prescribing of these drugs has been very slow. Single patient trials (SPTs) (also known as n-of-1 trials) offer a potential means of obtaining the evidence necessary to support or refute the use of several of the drug...

Single-patient (n-of-1) trials: a pragmatic clinical decision methodology for patient-centered comparative effectiveness research.

OBJECTIVE To raise awareness among clinicians and epidemiologists that single-patient (n-of-1) trials are potentially useful for informing personalized treatment decisions for patients with chronic conditions. STUDY DESIGN AND SETTING We reviewed the clinical and statistical literature on methods and applications of single-patient trials and then critically evaluated the needs for further met...

Are individual patient trials (n-of-1 trials) in rheumatology worth the extra effort?

"Me's me and you's you": Exploring patients' perspectives of single patient (n-of-1) trials in the UK

BACKGROUND The n-of-1 trial offers a more methodologically sound approach to determining optimum treatment for an individual patient than "trials of therapy" routinely conducted in clinical practice. However, such methodology is rarely used in the UK. This pilot study explores the acceptability of n-of-1 trials to patients in the UK. METHODS Patients with osteoarthritis of the knee were recru...

Mathematical modeling in immunotherapy of cancer: personalizing clinical trials.